DIAGNOSTIC AND THERAPEUTIC APPROACH TO PARKINSON'S DISEASE: A SYSTEMATIC REVIEW

Abstract

Objective: To report the main aspects involving Parkinson's disease, including diagnostic and therapeutic methods. Methodology: This is a systematic review focused on understanding the essential aspects of Parkinson's disease. The research was guided by the question: "What are the main aspects that permeate the evolution of Parkinson's disease, as well as what are the diagnostic resources and therapeutic approaches used in clinical practice?" To find answers, searches were performed in the PubMed database using four descriptors combined with the Boolean term "AND". This resulted in 2,069 articles, of which 23 were selected for analysis.  Results: Parkinson's disease (PD) is a progressive neurological disorder involving motor and non-motor symptoms, with diagnosis and treatment that require a multidisciplinary approach. The identification of clinical subtypes, such as the early or late form, and the profiles of tremor or postural instability, help to personalize the treatment. Levodopa is the standard treatment for most patients, although long-term use can cause complications. Conclusion: The future promises advances in precision medicine, improving the management of PD.  The review highlights the need for more research to identify biomarkers, improve early diagnosis, and develop effective treatments.