ENDOMETRIOSIS: A SYSTEMATIC REVIEW ON THE PATHOPHYSIOLOGY, COMPLICATIONS AND THERAPEUTIC APPROACHES FOR A COMPLEX CHRONIC DISEASE

Abstract

Objective: The general objective of this study is to analyze the scientific production on Endometriosis, identifying the main complications and treatments of this pathology. Methodology: This is a systematic review focused on understanding the essential aspects of Endometriosis. The survey was guided by the question, "What are the main complications and treatments for endometriosis?" To find answers, searches were performed in the PubMed database using five descriptors combined with the Boolean term "AND": (Infertility) AND (Endometriosis) AND (Endometrial diseases) and (Female infertility) AND (Endometrial diseases). This resulted in a total of 23 articles, of which 23 were selected for detailed analysis. Results: The main complications identified include chronic pelvic pain, infertility, and a variety of problems related to inflammation and the presence of endometriotic tissue outside the uterus. Hormonal treatments, such as progestins and GnRH agonists, are the most commonly used, although new therapies are being investigated, such as aromatase inhibitors and selective hormone receptor modulators. In addition, surgical approaches are often necessary for cases that are severe or resistant to medical treatments. The review also highlights the importance of early diagnosis and multidisciplinary management to improve patient outcomes. Conclusion: It is concluded that endometriosis is a complex condition that requires a multifaceted approach to its management. The characterization of complications and the development of effective treatment strategies are essential to improve the quality of life of patients. The combination of hormonal and surgical treatments and new therapies in development offers hope for more effective control of the disease.