DENGUE CONGÊNITA E MANIFESTAÇÕES NEUROLÓGICAS NEONATAIS: UMA REVISÃO DE ESCOPO
DOI:
https://doi.org/10.56238/ERR01v10n5-046Palabras clave:
Dengue, Transmisión Vertical de Enfermedades Infecciosas, Manifestaciones Neurológicas, NeonatoResumen
Justificación: A pesar del aumento de casos de dengue en embarazadas y la posibilidad de transmisión vertical con repercusiones neurológicas neonatales, los efectos de la infección congénita por el virus del dengue (DENV) siguen siendo poco conocidos y escasamente documentados en la literatura científica.
Objetivo: Mapear las manifestaciones neurológicas derivadas de la infección congénita por el virus del dengue en recién nacidos e identificar y explorar las lagunas científicas relacionadas con la mejora de la atención maternoinfantil para esta afección.
Métodos: La revisión exploratoria se realizó mediante una estrategia de búsqueda basada en la pregunta guía "¿Cuáles son las manifestaciones neurológicas neonatales derivadas del dengue congénito?", definiendo la población de estudio, el concepto y el contexto. Se realizaron búsquedas en las bases de datos Embase, LILACS, PubMed, Scopus, Web of Science y literatura gris hasta junio de 2024.
Resultados: Se identificaron 178 artículos. Tras aplicar los filtros metodológicos y los criterios de inclusión, se seleccionaron cinco estudios. Se presentaron datos bibliográficos, aspectos relacionados con el dengue congénito y las conclusiones del estudio.
Conclusión: La revisión exploratoria identificó evidencia de manifestaciones neurológicas neonatales asociadas con la infección congénita por DENV, destacando su impacto en la salud fetal y la necesidad de vigilancia clínica y neurológica en los neonatos expuestos.
Descargas
Referencias
Alallah, J., Albrah, A., & Alkhaldi, S. (2020). Congenital dengue in a Saudi neonate: A case report. Journal of Neonatal-Perinatal Medicine, 13(2), 279–282. https://doi.org/10.3233/NPM-190346
Anuradha, G., Sandya, M. R., & George, S. (2019). Spectrum of dengue morbidity in pregnancy and its impact on maternal and perinatal outcome. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 8(4), 1511–1517. https://doi.org/10.18203/2320-1770.ijrcog20191209
Arksey, H., & O’Malley, L. (2005). Scoping studies: Towards a methodological framework. International Journal of Social Research Methodology, 8(1), 19–32. https://doi.org/10.1080/1364557032000119616
Arragain, L., Dupont-Rouzeyrol, M., Folcher, N., Baudouin, L., Calvez, E., & Biron, A. (2017). Vertical transmission of dengue virus in the peripartum period and viral kinetics in newborns and breast milk: New data. Journal of the Pediatric Infectious Diseases Society, 6(4), 324–331. https://doi.org/10.1093/jpids/piw069
Ahuja, S., & Gharde, P. M. (2023). A narrative review of maternal and perinatal outcomes of dengue in pregnancy. Cureus, 15(11), e49429. https://doi.org/10.7759/cureus.49429
Ba, F., Diallo, A. K., Dia, I., & Diallo, M. (2025). Zika virus-related birth defects and neurological complications: A systematic review and meta-analysis. Reviews in Medical Virology, 35(2), e2596. https://doi.org/10.1002/rmv.2596
Basurko, C., Carles, G., Youssef, M., & Guindi, W. E. (2018). Estimating the risk of vertical transmission of dengue: A prospective study. The American Journal of Tropical Medicine and Hygiene, 98(6), 1826–1832. https://doi.org/10.4269/ajtmh.17-0798
Brasil, Ministério da Saúde, & Federação Brasileira das Associações de Ginecologia e Obstetrícia. (2024a). Manual para prevenção, diagnóstico e tratamento da dengue na gestação e no puerpério. São Paulo, Brazil: FEBRASGO; Brasília, Brazil: Ministério da Saúde.
Brasil, Ministério da Saúde. (2024b). Banco de dados do Sistema Único de Saúde – DATASUS. Brasília, Brazil: Ministério da Saúde.
Brasil, Ministério da Saúde, Centro de Operações de Emergências. (2024c). Número de casos prováveis de dengue por semana epidemiológica, Brasil, 2023 e 2024 (Informe Semanal, Edição nº 11, SE 01 a 16/2024). Brasília, Brazil: Ministério da Saúde.
Brasil, Ministério da Saúde. (2023). Saúde de A a Z: Dengue. Brasília, Brazil: Ministério da Saúde.
Brasil, P., & Lupi, O. (2017). Dengue infection during pregnancy and risk of preterm birth. The Lancet Infectious Diseases, 17(9), 885–886. https://doi.org/10.1016/S1473-3099(17)30406-7
Chye, J. K., Lim, C. T., Ng, K. B., Lim, J. M., George, R., & Lam, S. K. (1997). Vertical transmission of dengue. Clinical Infectious Diseases, 25(6), 1374–1377. https://doi.org/10.1086/516126
Fortuna, C., Marsili, G., & Venturi, G. (2024). Special issue “Arbovirus Diagnostics”. Viruses, 16(8), 1182. https://doi.org/10.3390/v16081182
Joanna Briggs Institute. (2021). Manual for evidence synthesis: Appendix 11.2 – PRISMA ScR extension fillable checklist. Adelaide, Australia: JBI Global Wiki.
Levac, D., Colquhoun, H., & O’Brien, K. K. (2010). Scoping studies: Advancing the methodology. Implementation Science, 5(1), 69. https://doi.org/10.1186/1748-5908-5-69
Maurice, A. S., Ervin, E., & Chu, A. (2021). Ebola, dengue, chikungunya, and Zika infections in neonates and infants. Clinics in Perinatology, 48(2), 311–329. https://doi.org/10.1016/j.clp.2021.03.006
Mulik, V., Dad, N., & Buhmaid, S. (2021). Dengue in pregnancy: Review article. European Journal of Obstetrics & Gynecology and Reproductive Biology, 261, 205–210. https://doi.org/10.1016/j.ejogrb.2021.04.036
Munn, Z., Peters, M. D. J., Stern, C., Tufanaru, C., McArthur, A., & Aromataris, E. (2018). Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Medical Research Methodology, 18(1), 143. https://doi.org/10.1186/s12874-018-0611-x
Paixão, E. S., Teixeira, M. G., Costa, M. D. C. N., & Rodrigues, L. C. (2018). Symptomatic dengue during pregnancy and congenital neurologic malformations. Emerging Infectious Diseases, 24(9), 1748–1750. https://doi.org/10.3201/eid2409.170361
Paixão, E. S., Barreto, F., Teixeira, M. D. G., Costa, M. D. C. N., & Rodrigues, L. C. (2016). Dengue during pregnancy and adverse fetal outcomes: A systematic review and meta-analysis. The Lancet Infectious Diseases, 16(7), 857–865. https://doi.org/10.1016/S1473-3099(16)00088-8
Parveen, S., Riaz, Z., Saeed, M., Javed, M., Khan, M. A., & Khan, A. H. (2023). Dengue hemorrhagic fever: A growing global menace. Journal of Water and Health, 21(11), 1632–1650. https://doi.org/10.2166/wh.2023.164
Peters, M. D. J., Godfrey, C., McInerney, P., Munn, Z., Tricco, A. C., & Khalil, H. (2020). Updated methodological guidance for the conduct of scoping reviews. JBI Evidence Synthesis, 18(10), 2119–2126. https://doi.org/10.11124/JBIES-20-00167
Pollock, D., Tricco, A. C., & Khalil, H. (2021). Undertaking a scoping review: A practical guide for nursing and midwifery students, clinicians, researchers, and academics. Journal of Advanced Nursing, 77(4), 2102–2113. https://doi.org/10.1111/jan.14743
Rathore, S. S., Oberoi, S., Hilliard, J., & Rathore, S. S. (2022). Maternal and foetal-neonatal outcomes of dengue virus infection during pregnancy. Tropical Medicine & International Health, 27(7), 619–629. https://doi.org/10.1111/tmi.13776
Santos, L. L. M., de Aquino, E. C., Sabino, E. C., & Duarte, A. J. S. (2023). Dengue, chikungunya, and Zika virus infections in Latin America and the Caribbean: A systematic review. Revista Panamericana de Salud Pública, 47, e103. https://doi.org/10.26633/RPSP.2023.103
Sharma, J. B., & Gulati, N. (1992). Potential relationship between dengue fever and neural tube defects in a northern district of India. International Journal of Gynecology & Obstetrics, 39(4), 291–295. https://doi.org/10.1016/0020-7292(92)90257-8
Singh, S., Kumar, A., & Bhatt, N. (2023). Neurological manifestations of perinatal dengue. Newborn, 2(2), 158–172. https://doi.org/10.5005/jp-journals-11002-0062
Tricco, A. C., Lillie, E., Zarin, W., O’Brien, K. K., Colquhoun, H., Levac, D., Moher, D., Peters, M. D. J., Horsley, T., Weeks, L., Hempel, S., Akl, E. A., Chang, C., McGowan, J., Stewart, L., Hartling, L., Aldcroft, A., Wilson, M. G., Garritty, C., … Straus, S. E. (2018). PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Annals of Internal Medicine, 169(7), 467–473. https://doi.org/10.7326/M18-0850
Usama, S., Assawawiroonhakarn, S., & Soonsawad, S. (2023). Vertical dengue transmission complicated with neonatal encephalitis. BMJ Case Reports, 16(12), e256589. https://doi.org/10.1136/bcr-2023-256589
World Health Organization. (2022). Dengue fever – Peru: Disease outbreak news. Geneva, Switzerland: World Health Organization.
World Health Organization. (2012). Global strategy for dengue prevention and control, 2012–2020. Geneva, Switzerland: World Health Organization.
Zander, L. R. M., de Aquino, E. C., Sabino, E. C., & Duarte, A. J. S. (2024). Neonatal congenital neurological sequelae resulting from maternal dengue: Scoping review protocol. Open Science Framework, 1–9. https://doi.org/10.17605/OSF.IO/3K7N4
