POST-ANESTHETIC NEUROCOGNITIVE CHANGES: A STUDY ON SUBTLE AND UNDERDIAGNOSED DYSFUNCTIONS IN GERIATRIC DOGS
DOI:
https://doi.org/10.56238/ERR01v10n7-033Keywords:
Veterinary Anesthesia, Geriatric Dogs, Cognitive Dysfunction, Neuroinflammation, Postoperative RecoveryAbstract
The increase in the longevity of dogs and, consequently, the demand for anesthetic procedures in geriatric patients, highlights the need to understand possible neurocognitive changes in the post-anesthetic period. Considering that brain aging reduces cognitive reserve and increases vulnerability to metabolic, hemodynamic, and pharmacological insults, the objective is to investigate, through an integrative review, the clinical signs, risk factors, and pathophysiological mechanisms associated with such changes, as well as their relationship with Canine Cognitive Dysfunction Syndrome (CCDS). To this end, a search was conducted in the main scientific databases between 2000 and 2024, including clinical and experimental studies and professional guidelines focused on anesthesia and veterinary geriatrics. It was observed that elderly dogs may experience disorientation, agitation, sleep disturbances, vocalization, and behavioral slowing after anesthesia, especially when there are systemic comorbidities or previous signs of neurodegeneration. These findings resemble the perioperative cognitive disorders described in humans and suggest the involvement of mechanisms such as neuroinflammation, oxidative stress, and synaptic dysfunction. It is concluded that such changes are plausible, relevant, and possibly underdiagnosed, reinforcing the need for standardized cognitive assessment protocols and individualized anesthetic practices that promote greater safety and well-being for geriatric dogs.
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References
AAHA. AAHA Senior Care Guidelines for Dogs and Cats. Journal of the American Animal Hospital Association, 2019.
BAETGE, C. L.; MATTHEWS, N. S. Anesthesia management in dogs and cats. Veterinary Clinics of North America: Small Animal Practice, v. 42, n. 4, p. 639–653, 2012. DOI: 10.1016/j.cvsm.2012.04.009.
FINSTERBUSCH, L. et al. Age-related renal changes and anesthetic implications in dogs. Veterinary Anaesthesia and Analgesia, 2018.
GAMA, M. Alterações fisiológicas e anestesia em cães geriátricos. Revista de Anestesiologia Veterinária, 2022.
HANNING, C. Postoperative cognitive dysfunction. British Journal of Anaesthesia, v. 95, n. 1, p. 82–87, 2005. DOI: 10.1093/bja/aei058.
HUGHES, J. Age-related respiratory decline in dogs. Journal of Veterinary Internal Medicine, 2008.
JONES, R. S. et al. Recovery quality in dogs following general anesthesia: a prospective study. Veterinary Anaesthesia and Analgesia, 2024.
KRUG, K. et al. Cognitive impairment in aged dogs: a spontaneous animal model of Alzheimer’s disease. Age (Dordrecht), v. 37, n. 1, p. 1–12, 2015. DOI: 10.1007/s11357-015-9769-0.
LANDSBERG, G. M.; NICHOL, J.; ARAUJO, J. A. Cognitive dysfunction syndrome: a disease of canine and feline brain aging. Veterinary Clinics of North America: Small Animal Practice, v. 42, p. 749–768, 2012. DOI: 10.1016/j.cvsm.2012.04.003.
OSELLA, M. C. et al. Canine cognitive dysfunction syndrome: prevalence, clinical symptoms and response to treatment. Veterinary Record, v. 161, p. 407–414, 2007. DOI: 10.1136/vr.161.12.407.
REDUQUE, L.; VERGHESE, J. Postoperative delirium. Annals of Geriatric Medicine and Research, 2013.
SESSLER, C. N. et al. The Richmond Agitation–Sedation Scale: validity and reliability in adult ICU patients. American Journal of Respiratory and Critical Care Medicine, v. 166, p. 1338–1344, 2002. DOI: 10.1164/rccm.2107138.
SILVA, R.; GAMA, M. População canina idosa e impactos na anestesiologia. Revista Brasileira de Medicina Veterinária, 2022.
VALENTIM, A. M.; GABURRO, R.; PARKER, K. Neurocognitive outcomes after exposure to anesthetics: translational perspectives. Neuroscience & Biobehavioral Reviews, v. 126, p. 361–375, 2021. DOI: 10.1016/j.neubiorev.2021.04.019.