HORMONE THERAPIES: SCIENTIFIC EVIDENCE BASED ON EVIDENCE AND INDISCRIMINATE USE

Abstract

Practices involving the manipulation of sex hormones have persisted for generations, generating positive and negative impacts on both physical and mental health. This study aims to address the latest evidence on the subject from the perspective of different authors, thus consolidating the most up-to-date knowledge on its benefits and disadvantages. This is an integrative review conducted in the SCIELO, LILACS, PUBMED, and BVS databases, including articles from 2020 to 2025. Eighty-five studies that presented significant relevance to the topic were selected. The conclusion is that hormone therapy, when used to treat adverse health conditions, especially those involving loss of muscle and bone mass, and with proper monitoring by a specialized healthcare professional, can significantly contribute to improving quality of life. Similarly, the use of these substances without clinical indications can have serious systemic consequences, particularly in the neurological, cardiac, hepatic, renal, and reproductive systems.

DOI: https://doi.org/10.56238/edimpacto2025.087-016