REDUCTION OF COMORBIDITIES DUE TO INVASIVE PROCEDURES AIMED AT WEIGHT LOSS

Authors

  • Maria Vitória Carvalho de Freitas Author
  • Rodrigo Avilino dos Santos Author
  • Camille Stephani Baccarin Author
  • Fernanda Mizutori Gigueira Author
  • Amanda Leticia Silva Lima Author
  • Eliza Apuzzo Author
  • Kawana de Sales Ferreira Author
  • Isabeli Molina Author

DOI:

https://doi.org/10.56238/arev8n5-030

Keywords:

Bariatric Surgery, Comorbidity, Metabolic Syndrome

Abstract

Obesity constitutes a global public health challenge, being intrinsically linked to metabolic and cardiovascular comorbidities that reduce quality of life. This systematic review, based on the analysis of 140 articles published between 2020 and 2024, evaluates the long-term impact of bariatric surgery—specifically gastric bypass and sleeve gastrectomy—on the remission of these conditions. The evidence demonstrates that, in addition to sustained weight loss, the procedures promote significant improvements in hypertension, dyslipidemia, and fatty liver disease, as well as high rates of type 2 diabetes remission and recovery of renal function. A substantial reduction in medication costs for metabolic syndrome was also observed. However, the lasting effectiveness of these interventions faces critical barriers, namely weight regain and the emergence of psychiatric and eating disorders in the postoperative period. It is concluded, therefore, that the clinical success of bariatric surgery imperatively depends on continuous multidisciplinary follow-up to mitigate relapses and ensure the maintenance of the metabolic benefits achieved.

Downloads

Download data is not yet available.

References

1. LAPEÑA-RODRÍGUEZ, M. et al. Excellent Results in Terms of Weight Loss and Type 2 Diabetes Control are Maintained 20 Years after Roux-en- Y Gastric Bypass. Journal of Gastrointestinal Surgery, v. 27, n. 11, p. 2580–2582, 18 jan. 2024. DOI: https://doi.org/10.1007/s11605-023-05734-5

2. VAN DER LAAN, L. et al. Comparable results 5 years after one anastomosis gastric bypass compared to Roux-en-Y gastric bypass: a propensity- score matched analysis. Surgery for Obesity and Related Diseases, 5 out. 2024. DOI: https://doi.org/10.1016/j.soard.2024.09.009

3. ABU DAYYEH, B. K. et al. Endoscopic sleeve gastroplasty for treatment of class 1 and 2 obesity (MERIT): a prospective, multicentre, randomised trial. Lancet (London, England), v. 400, n. 10350, p. 441–451, 6 ago. 2022. DOI: https://doi.org/10.1016/S0140-6736(22)01280-6

4. SHARAIHA, R. Z. et al. Five-Year Outcomes of Endoscopic Sleeve Gastroplasty for the Treatment of Obesity. Clinical Gastroenterology and Hepatology, v. 19, n. 5, p. 1051-1057.e2, 1 maio 2021. DOI: https://doi.org/10.1016/j.cgh.2020.09.055

5. POLJO, A. et al. Role of sleeve gastrectomy in improving metabolic syndrome: an overview. Updates in Surgery, 25 nov. 2024. DOI: https://doi.org/10.1007/s13304-024-02038-4

6. FELSENREICH, D. M. et al. Weight loss, weight regain, and conversions to Roux-en-Y gastric bypass: 10-year results of laparoscopic sleeve gastrectomy. Surgery for Obesity and Related Diseases, v. 12, n. 9, p. 1655–1662, nov. 2016. DOI: https://doi.org/10.1016/j.soard.2016.02.021

7. OUTÓN, S. et al. Presión arterial central en la obesidad mórbida y tras la cirugía bariátrica. Nefrología, v. 40, n. 3, p. 217–222, maio 2020. DOI: https://doi.org/10.1016/j.nefro.2019.09.004

8. KHOSROW NAJJARI et al. Laparoscopic gastric plication: A long- term follow-up and comparison of outcomes in severe vs. non-severe obesity. The American journal of surgery, v. 228, p. 102–106, 1 fev. 2024. DOI: https://doi.org/10.1016/j.amjsurg.2023.08.005

9. CRANE, J. D. et al. The Impact of Bariatric Surgery on Coronary Microvascular Function Assessed Using Automated Quantitative Perfusion CMR. JACC. Cardiovascular imaging, 1 ago. 2024.

10. OKIDA, L. F. et al. Bariatric surgery is associated with reduced admission for aortic dissection: a nationwide case-control analysis. Surgery for Obesity and Related Diseases, v. 17, n. 9, p. 1603–1610, 15 maio 2021. DOI: https://doi.org/10.1016/j.soard.2021.05.015

11. ARJONILLA SAMPEDRO, M. E. et al. Impact of ponderal loss after bariatric surgery on the cardiac structure and function. Medicina Clínica (English Edition), v. 159, n. 3, p. 109–115, ago. 2022. DOI: https://doi.org/10.1016/j.medcle.2022.07.007

12. MOREIRA, S. M. B. P. et al. Roux-en-Y Gastric Bypass Improves Adiponectin to Leptin Ratio and Inflammatory Profile in Severely Obese Women with and without Metabolic Syndrome: A Randomized Controlled Trial. Nutrients, v. 15, n. 15, p. 3312, 26 jul. 2023. DOI: https://doi.org/10.3390/nu15153312

13. BLANCHARD, C. et al. Roux-en-Y gastric bypass, but not sleeve gastrectomy, decreases plasma PCSK9 levels in morbidly obese patients. Diabetes & Metabolism, v. 46, n. 6, p. 480–487, 4 fev. 2020. DOI: https://doi.org/10.1016/j.diabet.2020.01.003

14. FREY, S. et al. Improvement in arterial stiffness (pOpmètre®) after bariatric surgery. Results from a prospective study. Annales d Endocrinologie, v. 81, n. 1, p. 44–50, 1 fev. 2020.

15. HOSSEININASAB, A. et al. The long-term impact of bariatric surgery on psoriasis symptoms and severity: a prospective observational study. Surgery for Obesity and Related Diseases, v. 20, n. 12, p. 1208–1213, 23 jul. 2024. DOI: https://doi.org/10.1016/j.soard.2024.07.011

16. ALEMRAJABI, M. et al. Effects of weight loss after bariatric surgery on the median and ulnar nerves conduction studies. The American Journal of Surgery, v. 225, n. 4, p. 753–757, 18 nov. 2022. DOI: https://doi.org/10.1016/j.amjsurg.2022.11.020

17. SUN, W. Y. L. et al. Idiopathic intracranial hypertension and bariatric surgery: a systematic review. Canadian Journal of Surgery, v. 63, n. 2, p. E123– E128, 1 mar. 2020 DOI: https://doi.org/10.1503/cjs.016616

18. SARMIENTO-COBOS, M. et al. Decreased Liver Volume after Bariatric Surgery and its Positive Impact on Liver Function Tests and Lipid Profile. Surgery for Obesity and Related Diseases, 19 dez. 2024 DOI: https://doi.org/10.1016/j.soard.2024.12.015

19. KWAK, M. et al. Bariatric surgery is associated with reduction in non- alcoholic steatohepatitis and hepatocellular carcinoma: A propensity matched analysis. The American Journal of Surgery, v. 219, n. 3, p. 504–507, 16 set. 2019. DOI: https://doi.org/10.1016/j.amjsurg.2019.09.006

20. GARCÍA RUIZ DE GORDEJUELA, A.; IBARZABAL, A.; OSORIO, J. Bariatric Surgery and Solid-Organ Transplantation. Transplantation Proceedings, v. 54, n. 1, p. 87–90, 29 dez. 2021.

21. LASSAILLY, G. et al. Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis. Gastroenterology, v. 159, n. 4, p. 1290-1301.e5, 1 out. 2020. DOI: https://doi.org/10.1053/j.gastro.2020.06.006

22. FUNES, D. R. et al. Changes in renal blood flow after surgically induced weight loss: can bariatric surgery halt the progression of chronic kidney disease? Surgery for Obesity and Related Diseases, v. 20, n. 5, p. 439–444, 25 nov. 2023. DOI: https://doi.org/10.1016/j.soard.2023.11.013

23. GARCÍA RUIZ DE GORDEJUELA, A.; IBARZABAL, A.; OSORIO, J. Bariatric Surgery and Solid-Organ Transplantation. Transplantation Proceedings, v. 54, n. 1, p. 87–90, 29 dez. 2021. DOI: https://doi.org/10.1016/j.transproceed.2021.11.008

24. MACHADO, F. P. et al. Weight Loss Through Bariatric Surgery in Men Presents Beneficial Effects on Sexual Function, Symptoms of Testosterone Deficiency, and Hormonal Profile. Sexual Medicine, v. 9, n. 4, p. 100400, ago. 2021. DOI: https://doi.org/10.1016/j.esxm.2021.100400

25. YANG, Ming; LIU, Shuai ; ZHANG, Chunye. The Related Metabolic Diseases and Treatments of Obesity. Healthcare, v. 10, n. 9, p. 1616–1616, 2022 DOI: https://doi.org/10.3390/healthcare10091616

26. ANEJA, A. Hypertension and Obesity. Recent Progress in Hormone Research, v. 59, n. 1, p. 169–205, 1 jan. 2004. DOI: https://doi.org/10.1210/rp.59.1.169

27. CHOBANIAN, A. V. et al. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension, v. 42, n. 6, p. 1206–1252, dez. 2003. DOI: https://doi.org/10.1161/01.HYP.0000107251.49515.c2

28. BLONDE, Lawrence; UMPIERREZ, Guillermo E; REDDY, S Sethu; et al. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan—2022 Update. Endocrine Practice, v. 28, n. 10, p. 923–1049, 2022.

29. KOUROSH SARKHOSH et al. The Impact of Sleeve Gastrectomy on Hypertension: A Systematic Review. Obesity Surgery, v. 22, n. 5, p. 832–837, 15 fev. 2012. DOI: https://doi.org/10.1007/s11695-012-0615-2

30. SALMINEN, P. et al. Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity: The SLEEVEPASS Randomized Clinical Trial. JAMA, v. 319, n. 3, p. 241–254, 16 jan. 2018. DOI: https://doi.org/10.1001/jama.2017.20313

31. CAVARRETTA, E. et al. Cardiac Remodeling in Obese Patients After Laparoscopic Sleeve Gastrectomy. World Journal of Surgery, v. 37, n. 3, p. 565– 572, 19 dez. 2012. DOI: https://doi.org/10.1007/s00268-012-1874-8

32. VOGLINO, C. et al. Cardiovascular Benefits and Lipid Profile Changes 5 Years After Bariatric Surgery: A Comparative Study Between Sleeve Gastrectomy and Roux-en-Y Gastric Bypass. Journal of Gastrointestinal Surgery, v. 24, n. 12, p. 2722–2729, 16 dez. 2019.

33. RUSSYAN MARK MABEZA et al. Bariatric surgery improves outcomes of hospitalizations for acute heart failure: a contemporary, nationwide analysis. Surgery for Obesity and Related Diseases, v. 19, n. 7, p. 681–687, 1 jul. 2023. DOI: https://doi.org/10.1016/j.soard.2022.12.027

34. AMGAD MENTIAS et al. Long-Term Cardiovascular Outcomes After Bariatric Surgery in the Medicare Population. v. 79, n. 15, p. 1429–1437, 1 abr. 2022.

35. FREY, S. et al. Improvement in arterial stiffness (pOpmètre®) after bariatric surgery. Results from a prospective study. Annales d Endocrinologie, v. 81, n. 1, p. 44–50, 1 fev. 2020. DOI: https://doi.org/10.1016/j.ando.2020.01.002

36. AMGAD MENTIAS et al. Long-Term Cardiovascular Outcomes After Bariatric Surgery in the Medicare Population. v. 79, n. 15, p. 1429–1437, 1 abr. 2022. DOI: https://doi.org/10.1016/j.jacc.2022.01.047

37. VOGLINO, C. et al. Cardiovascular Benefits and Lipid Profile Changes 5 Years After Bariatric Surgery: A Comparative Study Between Sleeve Gastrectomy and Roux-en-Y Gastric Bypass. Journal of Gastrointestinal Surgery, v. 24, n. 12, p. 2722–2729, 16 dez. 2019. DOI: https://doi.org/10.1007/s11605-019-04482-9

38. FARIAS, G. et al. Impact of dietary patterns according to NOVA food groups: 2 y after Roux-en-Y gastric bypass surgery. Nutrition, v. 74, p. 110746, jun. 2020. DOI: https://doi.org/10.1016/j.nut.2020.110746

39. LULAS BITER et al. Long-term effect of sleeve gastrectomy vs Roux- en-Y gastric bypass in people living with severe obesity: a phase III multicentre randomised controlled trial (SleeveBypass). The Lancet Regional Health - Europe, v. 38, p. 100836–100836, 1 mar. 2024. DOI: https://doi.org/10.1016/j.lanepe.2024.100836

40. SCHAUER, P. R. et al. Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes. New England Journal of Medicine, v. 366, n. 17, p. 1567–1576, 26 abr. 2012.

41. SCHAUER, P. R. et al. Bariatric Surgery versus Intensive Medical Therapy in Obese Patients with Diabetes. New England Journal of Medicine, v. 366, n. 17, p. 1567–1576, 26 abr. 2012. DOI: https://doi.org/10.1056/NEJMoa1200225

42. DAVOUDI, Z. et al. Inflammatory and metabolic markers and comorbidities remission following sleeve gastrectomy: A single center one-year cohort study. Primary care diabetes, v. 17, n. 3, p. 273–277, 7 mar. 2023. DOI: https://doi.org/10.1016/j.pcd.2023.03.001

43. LIU, Y. et al. A multi-center study on glucometabolic response to bariatric surgery for different subtypes of obesity. Frontiers in endocrinology, v. 13, p. 989202, mar. 2022. DOI: https://doi.org/10.3389/fendo.2022.989202

44. ABDALLA SALMAN, M. et al. Predictors of type-2 diabetes remission following bariatric surgery after a two-year follow up. Asian Journal of Surgery, mar. 2022. DOI: https://doi.org/10.1016/j.asjsur.2021.12.070

45. SOLEYMANI, T. et al. Bariatric surgery and COVID-19 outcomes: results from the PaTH to Health: Diabetes study. Surgery for Obesity and Related Diseases, v. 20, n. 11, p. 1039–1045, 4 jun. 2024. DOI: https://doi.org/10.1016/j.soard.2024.05.016

46. NUDOTOR, R. D. et al. Comparative Effectiveness of Roux-en Y Gastric Bypass Versus Vertical Sleeve Gastrectomy for Sustained Remission of Type 2 Diabetes Mellitus. Journal of Surgical Research, v. 261, p. 407–416, maio 2021. DOI: https://doi.org/10.1016/j.jss.2020.12.024

47. FORBES, H. et al. Bariatric surgery decreases prescription drug costs for metabolic syndrome: a Canadian population-based cohort study. Surgical Endoscopy, 30 set. 2024. DOI: https://doi.org/10.1007/s00464-024-11144-8

48. CHIA, T. et al. Prescription drug usage as measure of comorbidity resolution after bariatric surgery: a population-based cohort study. Surgical Endoscopy, v. 37, n. 11, p. 8601–8610, 25 jul. 2023. DOI: https://doi.org/10.1007/s00464-023-10294-5

49. FRANCISCA, Maria; PAPELBAUM, Marcelo; ANTÔNIO, Marco; et al. Mental health and weight regain after bariatric surgery: associations between weight regain and psychiatric and eating-related comorbidities. Archives of Endocrinology and Metabolism, v. 68, 2024. DOI: https://doi.org/10.20945/2359-4292-2023-0208

50. REMMEL, Shelby; NOOM, Madison; SANDSTROM, Reagan; et al. Preoperative comorbidities as a predictor of EBWL after bariatric surgery: a retrospective cohort study. Surgical Endoscopy, v. 38, n. 5, p. 2770–2776, 2024. DOI: https://doi.org/10.1007/s00464-024-10785-z

51. 1-PAGE, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting DOI: https://doi.org/10.31222/osf.io/v7gm2_v1

52. systematic reviews. BMJ, p. n71, 29 mar. 2021.

Published

2026-05-10

Issue

Section

Articles

How to Cite

DE FREITAS, Maria Vitória Carvalho; DOS SANTOS, Rodrigo Avilino; BACCARIN, Camille Stephani; GIGUEIRA, Fernanda Mizutori; LIMA, Amanda Leticia Silva; APUZZO, Eliza; FERREIRA, Kawana de Sales; MOLINA, Isabeli. REDUCTION OF COMORBIDITIES DUE TO INVASIVE PROCEDURES AIMED AT WEIGHT LOSS . ARACÊ , [S. l.], v. 8, n. 5, p. e13059, 2026. DOI: 10.56238/arev8n5-030. Disponível em: https://periodicos.newsciencepubl.com/arace/article/view/13059. Acesso em: 9 jun. 2026.